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Collagen – Why Molecular Weight Matters

The collagen molecule is quite large and complex, so when collagen is consumed naturally through food or supplements, its absorption is limited. Scientific studies show that low molecular weight collagen is much more readily absorbed by the human body. Low molecular weight collagen can more easily pass through the intestinal wall into the bloodstream, thus ensuring more effective delivery to the body’s tissues where it is needed, such as the skin, joints, and bones.

Hydrolyzed Collagen

In food, we usually consume high molecular weight collagen protein. To improve its absorption, collagen is hydrolyzed. During hydrolysis, collagen proteins are broken down into smaller chains (peptides). This breakdown results in hydrolyzed collagen with lower molecular weight peptides, which are more easily absorbed by the body. Regular collagen is a large-molecule protein that is not as easily absorbed.

Benefits of Hydrolyzed Collagen:

  • Better Absorption: Low molecular weight molecules can more easily penetrate the intestinal wall and be absorbed into the bloodstream, making them significantly more bioavailable than high molecular weight collagen.
  • Efficiency: Due to better absorption, low molecular weight collagen can more effectively reach the tissues that need collagen the most, such as the skin and joints.
  • Smaller Dosages: With improved absorption, large amounts of collagen are not needed.
  • Increased Water Solubility: Easily mixable with liquids, making it more convenient to use in dietary supplements and beverages.
  • Mild Flavor and Odor: Collagen broken down into very small particles can almost lack the typical collagen taste.

Scientific Studies

In recent years, several studies have been conducted to determine which type of collagen is best absorbed. A study published in the Journal of Agricultural and Food Chemistry states that low molecular weight collagen peptides are better absorbed in the human body and have greater bioavailability compared to high molecular weight collagen. The study showed that these peptides reach the bloodstream and tissues more quickly, ensuring faster and more effective impact.

Another study published in Nutrients examined the effects of low molecular weight collagen on skin hydration, elasticity, and wrinkle reduction. The results showed that participants who took low molecular weight collagen supplements experienced noticeable improvement in skin condition compared to the control group.

Based on these scientific studies, it’s clear that when choosing collagen supplements, attention should be given to their molecular weight to maximize their benefits.

Smaller Weight – Better Absorption

As mentioned, the hydrolysis process breaks down the collagen protein into peptides, which helps collagen molecules more easily pass through the intestinal wall and be absorbed into the bloodstream. Additionally, this form of collagen can be beneficial for athletes and active individuals, helping them recover more quickly after physical activity and reducing joint and muscle pain.

When choosing collagen, it’s important to consider the molecular weight. The smaller it is, the more easily it penetrates and is absorbed.

  • ≤2000 Daltons is considered low molecular weight collagen. The collagen in Dr. Ohhira’s formula has a molecular weight of only 1000 Da, and its collagen tripeptides are just 500 Da.
  • <5000 Daltons is regarded as a well-absorbed molecular weight. Collagen peptides are small enough to pass through the intestinal wall and be absorbed into the bloodstream.
  • 5000–10000 Daltons: Collagen peptides within this range can still be absorbed, but their absorption might be slightly lower than peptides of lower molecular weight.
  • >10000 Daltons: High molecular weight collagen peptides are less effective in terms of absorption. Due to their size, absorption in the intestines is quite limited.

It’s important to emphasize that supplements should be taken alongside a balanced diet and a healthy lifestyle. Dietary supplements should be used responsibly, taking individual health needs into account and, if necessary, consulting with a healthcare professional.

Information Sources:

 

“Journal of Agricultural and Food Chemistry”, tyrimas apie hidrolizuoto kolageno absorbciją.

“Nutrients”, tyrimas apie mažos molekulinės masės kolageno poveikį odai.