Collagen – why is molecular weight important?

2024-03-19

Collagen Molecule is Quite Large and Complex, So When Consumed Naturally Through Food or Supplements, Its Absorption is Limited. Scientific studies show that low molecular weight collagen is absorbed much better in the human body. Low molecular weight collagen penetrates the intestinal wall into the bloodstream more easily, ensuring a more efficient delivery to tissues that need it most – skin, joints, and bones.

Hydrolyzed Collagen

With food, we receive large molecular weight collagen protein. To improve absorption, collagen is hydrolyzed. During hydrolysis, collagen proteins are broken down into smaller chains (peptides). This breakdown results in hydrolyzed collagen having lower molecular weight peptides, which are more easily absorbed by the body. Regular collagen is a large-molecule protein, making it less easily absorbed.

Advantages of Hydrolyzed Collagen:

  1. Better Absorption: Low molecular weight molecules can more easily penetrate the intestinal wall and be absorbed into the bloodstream, leading to a significantly higher bioavailability than high molecular weight collagen.
  2. Effectiveness: Due to better absorption, low molecular weight collagen can more effectively reach tissues where collagen is most needed, such as skin and joints.
  3. Reduced Dosage: With improved absorption, large doses of collagen are not necessary.
  4. Higher Water Solubility: This allows it to be easily mixed with liquids, making it more convenient for use in food supplements and drinks.
  5. Milder Taste and Smell: Collagen broken down into very small particles may have little to no typical collagen taste.

Scientific Studies

Recent studies have explored which collagen is best absorbed. A study published in the Journal of Agricultural and Food Chemistry states that low molecular weight collagen peptides are better absorbed in the human body and have higher bioavailability compared to high molecular weight collagen. The study revealed that these peptides reach the bloodstream and tissues faster, ensuring quicker and more effective impact.

Another study published in the Nutrients journal examined the effects of low molecular weight collagen on skin hydration, elasticity, and wrinkle reduction. The results showed that participants taking low molecular weight collagen supplements experienced noticeable improvements in skin condition compared to the control group.

Based on these studies, it’s clear that the molecular weight of collagen supplements should be considered to maximize their benefits.

Lower Weight – Better Absorption

As mentioned, the hydrolysis process breaks down collagen protein into peptides, allowing collagen molecules to more easily pass through the intestinal wall and be absorbed into the bloodstream. Additionally, this collagen form may benefit athletes and active individuals, helping with faster recovery after physical exertion and reducing joint and muscle pain.

When choosing collagen, it’s important to consider the molecular weight. The smaller the molecular weight, the more permeable and efficiently absorbed the substance is.

  • ≤2000 Daltons is considered a low molecular weight for collagen. The collagen in Dr. OHHIRA® formulas has a molecular weight of only 1000 Da, and collagen tripeptides – just 500 Da!
  • <5000 Daltons are considered well-absorbed. Collagen peptides are small enough to pass through the intestinal wall and be absorbed into the bloodstream.
  • 5000-10000 Daltons: While collagen peptides in this range can still be absorbed, their absorption may be slightly lower compared to lower molecular weight peptides.
  • >10000 Da: High molecular weight collagen peptides are less efficient in terms of absorption. Due to their size, absorption in the intestines is quite limited.

It’s essential to emphasize that supplement intake should align with a balanced diet and a healthy lifestyle. Supplements should be used responsibly, taking individual health characteristics into account, and, if necessary, consulting with a healthcare professional.

Sources of Information:

  • Journal of Agricultural and Food Chemistry, study on hydrolyzed collagen absorption.
  • Nutrients, study on the effects of low molecular weight collagen on the skin.